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Diprotin A TFA

Catalog No. T11049Cas No. 209248-71-5

Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).

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Pack Size	Price	Availability	Quantity
2 mg	$49	5 days

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Questions

Product Introduction

Bioactivity

Description	Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).
In vitro	Diprotin A can increase the phosphorylation of Src and vascular endothelial cadherin (VE-cadherin) in human endothelial cells and destroy the connection between endothelial cells, which can be blocked by CXCR4 (SDF-1α receptor) or Src inhibitor Weaken.
In vivo	Diprotin A collectively induces vascular leakage by increasing the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway. In the model of retinopathy of prematurity, Diprotin A will not only increase retinal blood vessels, but also increase leakage. In addition, in the murine model of diabetic retinopathy, bupstatin A increases the phosphorylation of Src and VE-cadherin and aggravates retinal vascular leakage.
Alias	Ile-Pro-Pro (TFA)

Chemical Properties

Molecular Weight	455.47
Formula	C19H32F3N3O6
Cas No.	209248-71-5

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 77.5 mg/mL (170.15 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.1955 mL	10.9777 mL	21.9553 mL	109.7767 mL
5 mM	0.4391 mL	2.1955 mL	4.3911 mL	21.9553 mL
10 mM	0.2196 mL	1.0978 mL	2.1955 mL	10.9777 mL
20 mM	0.1098 mL	0.5489 mL	1.0978 mL	5.4888 mL
50 mM	0.0439 mL	0.2196 mL	0.4391 mL	2.1955 mL
100 mM	0.0220 mL	0.1098 mL	0.2196 mL	1.0978 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc